Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD
نویسندگان
چکیده
منابع مشابه
Oxidized LDL receptor 1 (OLR1) SNPs and CAD: a case-control association study in a North Indian population
The human lectin-like oxidized low-density lipoprotein receptor 1 (OLR1/LOX-1) is expressed on the endothelial cells, macrophages, and vascular smooth muscle cells. It internalizes Ox-LDL leading to multiple effects on endothelial dysfunctions and atherosclerosis (Knowles et al., 2008). The expression of OLR1 gene has been observed in vivo (placenta, lungs, brain, and liver) and in vitro (aorti...
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A cute myocardial infarction (AMI) is a significant cause of mortality and morbidity. Substantial data support a plausible role for oxidised LDL (oxLDL) in the aetiology of this disease. 2 The human OLR1 (or LOX 1) gene encodes the endothelium derived lectin-like oxidised low density lipoprotein (oxLDL) receptor, which is involved in the binding, internalisation, and proteolytic degradation of ...
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Recent studies have linked expression of lectin-like ox-LDL receptor 1 (OLR1) to tumorigenesis. We analyzed microarray data from Olr1 knockout (KO) and wild type (WT) mice for genes involved in cellular transformation and evaluated effects of OLR1 over-expression in normal mammary epithelial cells (MCF10A) and breast cancer cells (HCC1143) in terms of gene expression, migration, adhesion and tr...
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ژورنال
عنوان ژورنال: BMC Medical Genetics
سال: 2008
ISSN: 1471-2350
DOI: 10.1186/1471-2350-9-23